LymphedemaV1, Main, Exploration, bibRecord, 004010

Possible Genetic Predisposition to Lymphedema after Breast Cancer

Identifieur interne : 004010 ( Main/Exploration ); précédent : 004009; suivant : 004011

Possible Genetic Predisposition to Lymphedema after Breast Cancer

Auteurs : Beth Newman ; Felicity Lose ; Mary-Anne Kedda ; Mathias Francois ; Kaltin Ferguson ; Monika Janda ; Patsy Yates ; Amanda B. Spurdle ; Sandra C. Hayes

Source :

Lymphatic Research and Biology [ 1539-6851 ] ; 2012.

RBID : PMC:3311400

Descripteurs français

English descriptors

KwdEn :
- Biomarkers, Tumor (genetics), Breast Neoplasms (complications), Breast Neoplasms (epidemiology), Breast Neoplasms (genetics), Carcinoma, Ductal, Breast (complications), Carcinoma, Ductal, Breast (epidemiology), Carcinoma, Ductal, Breast (genetics), Carcinoma, Lobular (complications), Carcinoma, Lobular (epidemiology), Carcinoma, Lobular (genetics), Case-Control Studies, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genotype, Humans, Lymphatic System, Lymphedema (epidemiology), Lymphedema (etiology), Middle Aged, Polymorphism, Single Nucleotide (genetics), Prospective Studies, Queensland (epidemiology), Risk Factors.
MESH :
- chemical , genetics : Biomarkers, Tumor.
- geographic , epidemiology : Queensland.
- complications : Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular.
- epidemiology : Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Lymphedema.
- etiology : Lymphedema.
- genetics : Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Polymorphism, Single Nucleotide.
- Case-Control Studies, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genotype, Humans, Lymphatic System, Middle Aged, Prospective Studies, Risk Factors.

Abstract

AbstractBackground

Known risk factors for secondary lymphedema only partially explain who develops lymphedema following cancer, suggesting that inherited genetic susceptibility may influence risk. Moreover, identification of molecular signatures could facilitate lymphedema risk prediction prior to surgery or lead to effective drug therapies for prevention or treatment. Recent advances in the molecular biology underlying development of the lymphatic system and related congenital disorders implicate a number of potential candidate genes to explore in relation to secondary lymphedema.

Methods and Results

We undertook a nested case-control study, with participants who had developed lymphedema after surgical intervention within the first 18 months of their breast cancer diagnosis serving as cases (n=22) and those without lymphedema serving as controls (n=98), identified from a prospective, population-based, cohort study in Queensland, Australia. TagSNPs that covered all known genetic variation in the genes SOX18, VEGFC, VEGFD, VEGFR2, VEGFR3, RORC, FOXC2, LYVE1, ADM, and PROX1 were selected for genotyping. Multiple SNPs within three receptor genes, VEGFR2, VEGFR3, and RORC, were associated with lymphedema defined by statistical significance (p<0.05) or extreme risk estimates (OR <0.5 or >2.0).

Conclusions

These provocative, albeit preliminary, findings regarding possible genetic predisposition to secondary lymphedema following breast cancer treatment warrant further attention for potential replication using larger datasets.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311400

DOI: 10.1089/lrb.2011.0024
PubMed: 22404826
PubMed Central: 3311400

Affiliations:

Le document en format XML

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<term>Breast Neoplasms (complications)</term>
<term>Breast Neoplasms (epidemiology)</term>
<term>Breast Neoplasms (genetics)</term>
<term>Carcinoma, Ductal, Breast (complications)</term>
<term>Carcinoma, Ductal, Breast (epidemiology)</term>
<term>Carcinoma, Ductal, Breast (genetics)</term>
<term>Carcinoma, Lobular (complications)</term>
<term>Carcinoma, Lobular (epidemiology)</term>
<term>Carcinoma, Lobular (genetics)</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Lymphatic System</term>
<term>Lymphedema (epidemiology)</term>
<term>Lymphedema (etiology)</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Prospective Studies</term>
<term>Queensland (epidemiology)</term>
<term>Risk Factors</term>
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<term>Carcinome canalaire du sein ()</term>
<term>Carcinome canalaire du sein (génétique)</term>
<term>Carcinome canalaire du sein (épidémiologie)</term>
<term>Carcinome lobulaire ()</term>
<term>Carcinome lobulaire (génétique)</term>
<term>Carcinome lobulaire (épidémiologie)</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Lymphoedème (épidémiologie)</term>
<term>Lymphoedème (étiologie)</term>
<term>Marqueurs biologiques tumoraux (génétique)</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Queensland (épidémiologie)</term>
<term>Système lymphatique</term>
<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (génétique)</term>
<term>Tumeurs du sein (épidémiologie)</term>
<term>Études cas-témoins</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
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</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Queensland</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term>
<term>Carcinoma, Ductal, Breast</term>
<term>Carcinoma, Lobular</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Breast Neoplasms</term>
<term>Carcinoma, Ductal, Breast</term>
<term>Carcinoma, Lobular</term>
<term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term>
<term>Carcinoma, Ductal, Breast</term>
<term>Carcinoma, Lobular</term>
<term>Polymorphism, Single Nucleotide</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinome canalaire du sein</term>
<term>Carcinome lobulaire</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Tumeurs du sein</term>
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<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Carcinome canalaire du sein</term>
<term>Carcinome lobulaire</term>
<term>Lymphoedème</term>
<term>Queensland</term>
<term>Tumeurs du sein</term>
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</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Lymphatic System</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Risk Factors</term>
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<term>Carcinome canalaire du sein</term>
<term>Carcinome lobulaire</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Prédisposition génétique à une maladie</term>
<term>Système lymphatique</term>
<term>Tumeurs du sein</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<sec><title>Background</title>
<p>Known risk factors for secondary lymphedema only partially explain who develops lymphedema following cancer, suggesting that inherited genetic susceptibility may influence risk. Moreover, identification of molecular signatures could facilitate lymphedema risk prediction prior to surgery or lead to effective drug therapies for prevention or treatment. Recent advances in the molecular biology underlying development of the lymphatic system and related congenital disorders implicate a number of potential candidate genes to explore in relation to secondary lymphedema.</p>
</sec>
<sec><title>Methods and Results</title>
<p>We undertook a nested case-control study, with participants who had developed lymphedema after surgical intervention within the first 18 months of their breast cancer diagnosis serving as cases (<italic>n</italic>
=22) and those without lymphedema serving as controls (<italic>n</italic>
=98), identified from a prospective, population-based, cohort study in Queensland, Australia. TagSNPs that covered all known genetic variation in the genes <italic>SOX18</italic>
, <italic>VEGFC</italic>
, <italic>VEGFD</italic>
, <italic>VEGFR2, VEGFR3</italic>
, <italic>RORC</italic>
, <italic>FOXC2, LYVE1, ADM,</italic>
 and <italic>PROX1</italic>
 were selected for genotyping. Multiple SNPs within three receptor genes, <italic>VEGFR2, VEGFR3,</italic>
 and <italic>RORC</italic>
, were associated with lymphedema defined by statistical significance (<italic>p</italic>
<0.05) or extreme risk estimates (OR <0.5 or >2.0).</p>
</sec>
<sec><title>Conclusions</title>
<p>These provocative, albeit preliminary, findings regarding possible genetic predisposition to secondary lymphedema following breast cancer treatment warrant further attention for potential replication using larger datasets.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Ferguson, Kaltin" sort="Ferguson, Kaltin" uniqKey="Ferguson K" first="Kaltin" last="Ferguson">Kaltin Ferguson</name>
<name sortKey="Francois, Mathias" sort="Francois, Mathias" uniqKey="Francois M" first="Mathias" last="Francois">Mathias Francois</name>
<name sortKey="Hayes, Sandra C" sort="Hayes, Sandra C" uniqKey="Hayes S" first="Sandra C." last="Hayes">Sandra C. Hayes</name>
<name sortKey="Janda, Monika" sort="Janda, Monika" uniqKey="Janda M" first="Monika" last="Janda">Monika Janda</name>
<name sortKey="Kedda, Mary Anne" sort="Kedda, Mary Anne" uniqKey="Kedda M" first="Mary-Anne" last="Kedda">Mary-Anne Kedda</name>
<name sortKey="Lose, Felicity" sort="Lose, Felicity" uniqKey="Lose F" first="Felicity" last="Lose">Felicity Lose</name>
<name sortKey="Newman, Beth" sort="Newman, Beth" uniqKey="Newman B" first="Beth" last="Newman">Beth Newman</name>
<name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
<name sortKey="Yates, Patsy" sort="Yates, Patsy" uniqKey="Yates P" first="Patsy" last="Yates">Patsy Yates</name>
</noCountry>
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Serveur d'exploration sur le lymphœdème

Possible Genetic Predisposition to Lymphedema after Breast Cancer

Possible Genetic Predisposition to Lymphedema after Breast Cancer

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Descripteurs français

English descriptors

Abstract

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